T. Nakai et al., Electrophysiological effect of adenosine triphosphate and adenosine on atrial and ventricular action potential duration in humans, JPN CIRC J, 64(6), 2000, pp. 430-435
Citations number
16
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Bolus injection of adenosine triphosphate (ATP) or adenosine is widely used
clinically for terminating supraventricular tachycardia. However, bolus in
jection of these drugs has been reported to provoke atrial fibrillation (Af
ib). The effects of ATP and adenosine on the monophasic action potential du
ration (MAPD) of atrial and ventricular muscle was investigated, as well as
the changes in the spatial distribution of atrial functional refractorines
s caused by adenosine. Bolus injection of ATP and adenosine shortened atria
l MAPD; no change was observed in the ventricle. Because local f-f interval
s during atrial fibrillation correlate with the atrial refractory period, c
hanges in mean f-f intervals in the right atrial appendage, His bundle regi
on, coronary sinus ostium and distal coronary sinus were compared before an
d after injection of adenosine during induced Afib. Maximal shortening of f
-f intervals was observed in the right atrial appendage. Inhomogeneous shor
tening of atrial refractoriness may account for the Afib following bolus in
jection of ATP or adenosine.