In vivo splicing and functional characterization of Mycobacterium leprae RecA

Authors
Frischkorn, K Springer, B Bottger, EC Davis, EO Colston, MJ Sander, P
Citation
K. Frischkorn et al., In vivo splicing and functional characterization of Mycobacterium leprae RecA, J BACT, 182(12), 2000, pp. 3590-3592
Citations number
17
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
182
Issue
12
Year of publication
2000
Pages
3590 - 3592
Database
ISI
SICI code
0021-9193(200006)182:12<3590:IVSAFC>2.0.ZU;2-H
Abstract
The RecA proteins from Mycobacterium tuberculosis and Mycobacterium leprae contain inteins. In contrast to the M. tuberculosis RecA, the M leprae RecA is not spliced in Escherichia coli, We demonstrate here that M. leprae Rec A is functionally spliced in Mycobacterium smegmatis and produces resistanc e toward DNA-damaging agents and homologous recombination.