Jj. Eron et al., The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen (AIDS clinical trials group protocol 850), J INFEC DIS, 181(5), 2000, pp. 1622-1628
Antiretroviral therapy may lead to decreased shedding of human immunodefici
ency virus type 1 (HIV-1) in genital secretions. Thirty men, 19 receiving a
mprenavir and ii receiving amprenavir, zidovudine, and lamivudine, donated
blood and semen while undergoing treatment, to evaluate the effects of thes
e medications on HIV-1 shedding in semen. Before therapy, 4 men had HIV-1 R
NA levels in seminal plasma >6.0 log(10) (1 million) copies/mL, markedly hi
gher than levels in blood plasma. Most men (77%) had HIV-1 RNA levels in se
minal plasma below the limit of quantification during therapy. Amprenavir a
lone suppressed I HIV-1 RNA levels to <400 copies/mL in seminal plasma in t
he majority of patients, the first direct demonstration of the antiretrovir
al effects of a protease inhibitor in the male genital tract. However, 8 me
n (27%) had measurable HIV-1 in seminal plasma at their last study visit, 4
with increasing levels. Persistent replication of HIV in the genital tract
may have implications for the selection of resistant virus and sexual tran
smission of HIV-1.