Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media

The immune response was evaluated in 11 children with Streptococcus pneumon iae and in 9 children with Moraxella catarrhalis otitis media. The age of t he children had a range of 4-32 months. The mean IgG, IgM, and IgA antibody responses to surface protein A (PspA) of S, pneumoniae in sera from childr en at the acute and convalescent stages were 4864 versus 5831 ng/mL, P < .0 5, 1075 versus 3752 ng/mL, P < .05, and 67 versus 93 ng/mL, nonsignificant (NS), respectively. The mean IgG, IgM, and IgA antibody responses to the hi gh-molecular-weight outer membrane protein (UspA) of nl. catarrhalis in ser a from children at acute and convalescent stages were 710 versus 935 mg/mL, NS; 1895 versus 2646 ng/mL, NS; and 121 versus 204 ng/mL, P < .05, respect ively. These data show that PspA and UspA are immunogenic in children after otitis media.