Disseminated and recurrent sarcoid-like granulomatous panniculitis due to bovine collagen injection

Three to five percent of patients treated with injectable collagen implants have adverse local reactions. Systemic signs or symptoms are infrequent. W e describe the case of a 53-yearold woman who developed local and general c omplaints 2 months after receiving two collagen injections in both nasolabi al folds. She presented asthenia, malaise, polyarthralgia and inflammatory nodular panniculitis in the places of injection as well as on the forearms and lower extremities. Skin testing was compatible with hypersensitivity to collagen. This case raises the question as to whether the injection of ani mal-derived collagen induces manifestations similar to those observed in co nnective autoimmune diseases or human adjuvant disease.