Screening catalysts for the catalytic exchange of hydrogen by tritium using magnetic labeling

Isotope labeling is an important method to evaluate drugs and compounds for agricultural use. Therefore, a fast and convenient method to selectively e xchange hydrogen against non-radioactive deuterium or radioactive tritium i n the final product is desirable. PHIP-NMR investigations of the influence of CO on the selective exchange of the geminal protons in styrene show that CO increases the efficiency of the selective exchange non-linearly and sup presses the hydrogenation of styrene to ethylbenzene.