Voltammetric methods for analytical determination of fleroxacin in Quinodis (R) tablets

The direct current (dc) and differential pulse (dp) polarographic reduction of fleroxacin was done in a wide pH range from 2.38 to 13.00. The appropri ate buffer choice was made for its dp polarographic determination in a rang e from 1.845 to 16.926 mu g/ml, at pH 8.50. The adsorptive properties of fl eroxacin were investigated in order to achieve an increase in sensitivity a nd a possibility of fleroxacin determination by applying the adsorptive str ipping voltammetric method. The adsorptive processes at the hanging mercury drop electrode were investigated in Britton-Robinson and berate buffers. A dsorptive preconcentration followed by differential-pulse cathodic strippin g showed one wave at similar to - 1.1 V being the most sensitive for analyt ical determination of fleroxacin. Two linear ranges were obtained. the firs t one from 18.465 to 258.51 ng/ml, and the second one from 3.693 to 18.465 ng/ml. (C) 2000 Elsevier Science B.V. All rights reserved.