T. Sawada et al., Postoperative adhesion prevention with an oxidized regenerated cellulose adhesion barrier in infertile women, J REPRO MED, 45(5), 2000, pp. 387-389
OBJECTIVE: To evaluate the efficacy of an oxidized regenerated cellulose ad
hesion barrier as an adjuvant in preventing postoperative adhesions in infe
rtile women undergoing reconstructive surgery.
STUDY DESIGN: Thirty-eight cases of reconstructive surgery that could be fo
llowed up for more than two years (myomectomy 19, cystectomy 5, tuboplasty
10, uteroplasty 4) at the Fujita Health University Hospital were evaluated
retrospective ly. The barrier Interceed, Johnson & Johnson) was used to cov
er the surgical site in 23 of these cases (Interceed + group); no adjuvant
was used in 15 cases, which represent the surgical control group (Interceed
- group), including 23 second-look operation cases (16 in the Interceed and 7 in the control group). Postoperative adhesion prevention and pregnanc
y rates were estimated.
RESULTS: At the second-look operation, six cases (37.5%) in the Interceed group and six (85.7%) in the Interceed - group had postoperative adhesions
. No significant difference was found in either intensity or area covered w
ith adhesions between the two groups. Eighteen cases (78.3%) in the Interce
ed + and seven (46.7%) in the Interceed - group conceived during the follow
-up period.
CONCLUSION: The use of Interceed significantly reduced the rate of postoper
ative adhesion-formation, with a statistically significant increase in the
pregnancy rate as compared to the surgical controls.