Enoxaparin in unstable angina and non-Q-wave myocardial infarction: Results of multicenter study in Russia

Two hundred eighty four patients admitted to hospital with the diagnosis of unstable angina (n=216) or non-Q-wave myocardial infarction (n=68 or 25,1% ) aged 62,3+/-10,2 years (63% males) were enrolled in open, non-comparative , multicenter study of safety and efficacy of a low molecular weight hepari n enoxaparin. Previous myocardial infarction, history of hypertension, diab etes and congestive heart failure had 38,9, 78,2, 16,9 and 27,2% of patient s, respectively. Majority (75,3%) of patients were hospitalized within 48 h ours after onset of the last episode of prolonged (greater than or equal to 10 minutes] chest pain at rest. In large proportion (44%) of patients the index attack of pain developed while they were on aspirin. Ischemic changes on admission ECC were registered in 92,6% of patients. Non-Q-wave myocardi al infarction was finally diagnosed in 25,1% of patients. Enoxaparin was ad ministered subcutaneously 1 mg/kg every 12 hours during 2-8 (median 4) days . Aspirin received 91,5% of patients. None of the patients was treated inva sively. During first 15 days of treatment (or before discharge whichever fi rst) were observed tow mortality rate (n=1 or 0,35%), number of non-fatal ( re)infarctions (n=3 or 1,05%) as well as rates of major (n=1 or 0,35%) and minor hemorrhages (n=14 or 4,9%). No significant changes of platelet count, hemoglobin and hematocrit were noted.