Effect of ionic strength on the electrochemical behavior of glutathione ona phospholipid self-assembled monolayer on mercury

A voltammetric study of the permeability of redox couple oxidized glutathio ne/reduced glutathione (GSSG/GSH) through a membrane biomimetic model has b een carried out. The biomimetic model has been obtained by deposition of a self-assembled monolayer of phospholipid on a mercury electrode. Experiment al results show that the oxidized form of GSSG is able to penetrate through the phospholipid monolayer to produce an irreversible adsorption peak on t he mercury surface. The dependence of current and peak potential on the ion ic strength has been studied. No voltammetric signal has been obtained for the reduced form GSH. A simple model of the double layer is employed to ana lyze the experimental curves. Results obtained are briefly compared with so me studies of transport carried out in cell cultures.