Forty-four Hong Kong Chinese adults comprising 10 cases of fingernail and 4
2 cases of toenail onychomycosis were recruited for a 5-weekly itraconazole
pulse therapy. Each pulse consisted of seven consecutive daily 400 mg dose
s with a 3-week interval between treatments. All patients in the fingernail
group and 37 in the toenail group completed the study. The clinical cure,
clinical response and mycological cure rates at week 36 were 70, 90 and 90%
for fingernail and 35, 81 and 68% for toenail groups, respectively. Side-e
ffects including biochemical abnormalities were minimal, and returned to no
rmal upon cessation of treatment. We conclude that itraconazole pulse thera
py is very effective, safe and well-tolerated for fingernail and toenail on
ychomycosis.