Electrophoretic characterization of a gamma-1-heavy chain disease

This report describes a new case of gamma-1-heavy chain disease found in a woman with malignant lymphoproliferative disease. The patient's serum and u rine containing gamma-1-heavy chains were analyzed using different electrop horetic approaches, especially two-dimensional electrophoresis and immunobl otting analysis. In a serum sample, five sets of gamma-1 -heavy chain spots differing in molecular weight with acidic pi values and one set of more ba sic gamma-1-heavy chain spots were found. The major group of spots exhibite d molecular weight in the range from 29 to 39 kDa. Examination of urine sam ple proved the presence of the more basic set of gamma-1-heavy chain spots and two acidic groups, including 29 to 39 kDa set.