Synthesis and antiviral activity of 3-(beta-D-ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide

Authors
Pratap, R Yarovenko, VN
Citation
R. Pratap et Vn. Yarovenko, Synthesis and antiviral activity of 3-(beta-D-ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide, NUCLEOS NUC, 19(5-6), 2000, pp. 845-849
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
5-6
Year of publication
2000
Pages
845 - 849
Database
ISI
SICI code
1525-7770(2000)19:5-6<845:SAAAO3>2.0.ZU;2-R
Abstract
3-(beta-D-Ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide (5) was prepared by condensation reaction of amidoxime 6 with monoethyl oxaloyl chloride follo wed by reaction with ammonia. The compound 5, however, did not exhibit any significant activity against herpes simplex virus type-1 (HSV-1) and semlik i forest virus (SFV).