Synthesis and NMR characterization of diastereomeric C(PSMe)G derivatives

Authors
Machytka, D Sagi, G Kajtar-Peredy, M Gacs-Baitz, E
Citation
D. Machytka et al., Synthesis and NMR characterization of diastereomeric C(PSMe)G derivatives, NUCLEOS NUC, 19(5-6), 2000, pp. 903-915
Citations number
17
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
5-6
Year of publication
2000
Pages
903 - 915
Database
ISI
SICI code
1525-7770(2000)19:5-6<903:SANCOD>2.0.ZU;2-S
Abstract
Synthesis and stereochemical characterization of enantiomerically pure C(PS Me)G derivatives by NMR methods are reported. The effect of 5'-dimethoxytri tyl on the conformational properties is described. It was found that in P-d iastereomers the conformational differences about the C3'-O3' bond, as disc ernible from the Delta J values, are enhanced by the presence of this prote cting group.