A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone

Authors
Gao, K Orgel, LE
Citation
K. Gao et Le. Orgel, A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone, NUCLEOS NUC, 19(5-6), 2000, pp. 935-940
Citations number
8
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
5-6
Year of publication
2000
Pages
935 - 940
Database
ISI
SICI code
1525-7770(2000)19:5-6<935:ACSOAN>2.0.ZU;2-9
Abstract
The nucleoside analogue 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)- 2-pyrimidinone (5) was prepared from the corresponding 4-methyl pyrimidinon e nucleoside by means of the Vilsmeier reaction. The unprotected nucleoside can be phosphorylated directly with phosphorus oxychloride in triethyl pho sphate.