Wj. Gradishar et al., A pilot trial of suramin in metastatic breast cancer to assess antiangiogenic activity in individual patients, ONCOL-BASEL, 58(4), 2000, pp. 324-333
Suramin is a polysulfonated naphthylurea with multiple potential mechanisms
of action against tumors, including the ability to bind growth factors kno
wn to promote tumor angiogenesis, Using an established fixed dosing scheme
for the administration of suramin in patients, a pilot study was conducted
in patients with progressive, metastatic breast cancer, The primary objecti
ve of this trial is to define the effect of suramin on the angiogenic activ
ity in individual patients using in vitro laboratory assays. The secondary
objective was to assess the antitumor effect of suramin in a population of
metastatic breast cancer patients. No objective tumor responses were observ
ed in any of the 9 patients who received treatment with suramin, however 1
patient did maintain stable disease status, The strength of angiogenic acti
vity present in patient samples was assessed by testing patient plasma in t
he capillary endothelial cell migration assay, Angiogenic activity followed
over time was lowest in patients with the highest suramin concentrations a
nd highest in patients with the lowest suramin concentrations. We conclude
that it is feasible to continually monitor the activity of antiangiogenic a
gents in individual patients without relying on clinical tumor response, co
pyright (C) 2000 S. Karger AG, Basel.