Cyclodidemniserinol trisulfate, a sulfated serinolipid from the Palauan ascidian Didemnum guttatum that inhibits HIV-1 integrase

Authors
Mitchell, SS Rhodes, D Bushman, FD Faulkner, DJ
Citation
Ss. Mitchell et al., Cyclodidemniserinol trisulfate, a sulfated serinolipid from the Palauan ascidian Didemnum guttatum that inhibits HIV-1 integrase, ORG LETT, 2(11), 2000, pp. 1605-1607
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
11
Year of publication
2000
Pages
1605 - 1607
Database
ISI
SICI code
1523-7060(20000601)2:11<1605:CTASSF>2.0.ZU;2-W
Abstract
[GRAPHICS] Bioassay-guided fractionation of extracts of the Palauan ascidian Didemnum guttatum led to the isolation of cyclodidemniserinol trisulfate (1) as an i nhibitor of HIV-1 integrase, which is an attractive target for anti-retrovi ral chemotherapy. The structure of cyclodidemniserinol trisulfate (1), the stereochemistry of which was only partially determined, was elucidated by i nterpretation of NMR and mass spectral data.