Tg. Purdie et al., Dynamic contrast enhanced CT measurement of blood flow during interstitiallaser photocoagulation: comparison with an Arrhenius damage model, PHYS MED BI, 45(5), 2000, pp. 1115-1126
One effect of heating during interstitial laser photocoagulation (ILP) is t
o directly destroy the tumour vasculature resulting in a loss of viable blo
od supply. Therefore, blood how measured during and after treatment can be
a useful indicator of tissue thermal damage. In this study, the effect of I
LP treatment on rabbit thigh tumours was investigated by measuring blood fl
ow changes using dynamic contrast enhanced computed tomography (CT).
The CT measured changes in blood flow of treated tumour tissue were fitted
to an Arrhenius model assuming first order rate kinetics. Our results show
that changes in blood flow of tumour tissue distant from surrounding normal
tissue are well described by an Arrhenius model. By contrast, the temperat
ure profile of tumour tissue adjacent to normal tissue must be modified to
account for heat dissipation by the latter. Finally, the Arrhenius paramete
rs derived in the study are similar to those derived by heating tumour tiss
ue to a lower temperature (<47 degrees C) than the current study.
In conclusion, CT can be used to monitor blood flow changes during ILP and
these measurements are related to the thermal damage predicted by the Arrhe
nius model.