Ch. Cho et al., Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats, PLANTA MED, 66(4), 2000, pp. 348-351
We studied the protective effects of polysaccharides isolated from the root
of Angelica sinensis (Oliv.) (Danggui) on gastrointestinal damage induced
by ethanol or indomethacin in rats. Oral administration of ethanol provoked
a marked hemorrhagic damage in the glandular mucosa, which was accompanied
with a significant increase of myeloperoxidase (MPO) activity, a marker en
zyme for inflammation and neutrophil infiltration. An extract from Angelica
, which mainly consisted of polysaccharides (95%) (AP), dose-dependently pr
evented gastric mucosal damage. This ulcer protective effect could last at
least 12 h after administration. Prostaglandin E-2 produced a similar anti-
lesion effect. AP and prostaglandin E-2 also reduced mucosal MPO activity.
Indomethacin-induced gastrointestinal damage, another neutrophil-dependent
lesion model in the gastrointestinal tract, was also prevented by AP pretre
atment. The present findings suggest that polysaccharides from Angelica pos
sess an anti-inflammatory action, perhaps through the inhibitory action on
neutrophil infiltration in the gastrointestinal mucosa. AP could potentiall
y be useful to prevent any neutrophil-dependent mucosal injury in the gastr
ointestinal tract.