Agelasine F from a Philippine Agelas sp sponge exhibits in vitro antituberculosis activity

Authors
Mangalindan, GC Talaue, MT Cruz, LJ Franzblau, SG Adams, LB Richardson, AD Ireland, CM Concepcion, GP
Citation
Gc. Mangalindan et al., Agelasine F from a Philippine Agelas sp sponge exhibits in vitro antituberculosis activity, PLANTA MED, 66(4), 2000, pp. 364-365
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
4
Year of publication
2000
Pages
364 - 365
Database
ISI
SICI code
0032-0943(200005)66:4<364:AFFAPA>2.0.ZU;2-T
Abstract
Marine sponge samples were collected in Baler, Aurora, Philippines, and ext racts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some dr ug resistant strains of Mycobacterium tuberculosis in vitro at concentratio ns as low as 3.13 mu g/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13-22 mu g/ml which was below the I C50 for Vero cells (34 mu g/ml).