Sipandinolide: A butenolide including a novel type of carbon skeleton fromSiparuna andina

Authors
Jenett-Siems, K Siems, K Jakupovic, J Solis, PN Gupta, MP Mockenhaupt, FP Bienzle, U Eich, E
Citation
K. Jenett-siems et al., Sipandinolide: A butenolide including a novel type of carbon skeleton fromSiparuna andina, PLANTA MED, 66(4), 2000, pp. 384-385
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
4
Year of publication
2000
Pages
384 - 385
Database
ISI
SICI code
0032-0943(200005)66:4<384:SABIAN>2.0.ZU;2-D
Abstract
From a lipophilic extract of leaves of Siparuna andina (Monimiaceae), which exhibited antiplasmodial activity in vitro, two new compounds have been is olated: sipandinolide (1), a compound with a novel type of carbon skeleton and (-)-cis-3-acetoxy-4',5,7-trihydroxyflavanone (2). Their structures were established by spectroscopic methods; 2 showed moderate antiplasmodial act ivity whereas 1 was inactive.