EFFECT OF OCTREOTIDE ON HUMAN SPHINCTER OF ODDI MOTILITY FOLLOWING LIVER-TRANSPLANTATION

The effect of octreotide on sphincter of Oddi motility was investigate d in six liver transplant patients, employing percutaneous (through th e T-tube tract) manometry. Continuous and simultaneous sphincter of Od di and duodenal motor activities were recorded before and for 60 min a fter the administration of octreotide (100 mu g subcutaneously) and af ter the injection of cholecystokinin (0.02 mu g/kg intravenously). Wit h octreotide, contraction frequency and basal pressure significantly i ncreased (P < 0.05). This effect lasted more than 60 min? long after o ctreotide-induced duodenal migrating motor complex phase III activity had ceased. Sphincter of Oddi contraction amplitude and duration were unaffected by octreotide. Subsequent cholecystokinin administration tr ansiently reduced sphincter of Oddi basal pressure and contraction fre quency. We conclude that octreotide significantly increases sphincter of Oddi basal pressure and contraction frequency. This effect is disti nct from octreotide induction of migrating motor complex phase III act ivity, persists for a prolonged period, and is inhibited by cholecysto kinin.