Hemochromatosis heterozygotes may constitute a radiation-sensitive subpopulation

A primary mechanism of radiation-induced DNA damage is by generation of fre e radicals. Chronically increased oxidative stress from elevated levels of iron in the body may increase radiation sensitivity by decreasing cellular oxygen radical scavenging capability. Hemochromatosis heterozygotes have el evated body iron. Low-level radiation sensitization by iron may be particul arly pertinent for risk of breast cancer, Since 10% of the population appea rs to be heterozygous for the hemochromatosis gene, a radiosensitizing effe ct would have pervasive implications. (C) 2000 by Radiation Research Societ y.