Derivatization for electrospray ionization-mass spectrometry. 4. Alkenes and alkynes

A survey of derivatization strategies and prospective derivatization reacti ons for conversion of simple alkenes and alkynes to 'electrospray-active ' species is presented. General synthetic strategies are discussed and illust rative examples of prospective derivatives prepared from model compounds ar e presented along with their electrospray ionization (ES) mass spectra, The identified derivatives of these neutral, nonpolar analytes are either ioni c or are ionizable in solution through Bronsted acid/base chemistry, by Lew is acid/base chemistry, or by chemical or electrochemical electron-transfer chemistry. Once ionized, the derivatives are expected to be amenable to de tection by electrospray ionization-mass spectrometry. Derivatives are ident ified for positive and negative ion analysis of both alkenes and alkynes. C opyright (C) 2000 John Wiley & Sons, Ltd.