More and more laboratories are forced to document evidently that experiment
al results were achieved compliant with the regulatory of Good Laboratory P
ratice (GLP). Thus, also for the imaging plate technique, which is widely u
sed in whole-body autoradiography, it is necessary to provide procedures fo
r formal validation and continuous quality control. Therefore, several Euro
pean pharmaceutical companies agreed to carry out a project on this subject
. This part considers the technical validation. Methods to prove uniform se
nsitivity and resolution of the technique were developed and are suggested
as standard operation procedures and demonstrated, as well, by examples usi
ng the isotope C-14. The high linearity of the detection method is shown by
performing a calibration of the image data to the applied radioactivity. (
C) 2000 Academic Press.