Preparation of new pyridoacridine derivatives and formal synthesis of 11-hydroxyascididemine

Authors
Alvarez, M Feliu, L Ajana, W Joule, JA
Citation
M. Alvarez et al., Preparation of new pyridoacridine derivatives and formal synthesis of 11-hydroxyascididemine, TETRAHEDRON, 56(23), 2000, pp. 3703-3708
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
23
Year of publication
2000
Pages
3703 - 3708
Database
ISI
SICI code
0040-4020(20000602)56:23<3703:PONPDA>2.0.ZU;2-M
Abstract
The preparation of pyrido[2,3,4-kl]acridin-6-ones substituted at position 4 following our previous methodology is described. A new synthetic route for the preparation of aminopyridoacridone 16, used before for the synthesis o f the 11-hydroxyascididemine, is described. The cytotoxic activity of pyrid oacridones 19 and 20 in four cell lines is reported. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.