Rhodium-catalysed racemisation of N-acyl alpha-amino acids

Authors
Hateley, MJ Schichl, DA Kreuzfeld, HJ Beller, M
Citation
Mj. Hateley et al., Rhodium-catalysed racemisation of N-acyl alpha-amino acids, TETRAHEDR L, 41(20), 2000, pp. 3821-3824
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3821 - 3824
Database
ISI
SICI code
0040-4039(20000521)41:20<3821:RRONAA>2.0.ZU;2-N
Abstract
The first transition metal-catalysed racemisation of N-acyl alpha-amino aci ds, which is of importance for kinetic resolution processes, is described. Enantiomerically pure N-acyl cx-amino acids were efficiently racemised unde r mild conditions using various rhodium complexes as catalysts, e.g. [Rh(co d)Cl](2), in the presence of phosphines. (C) 2000 Elsevier Science Ltd. All rights reserved.