Total synthesis of 4(RS)-F-4t-isoprostane methyl ester

Authors
Durand, T Guy, A Vidal, JP Viala, J Rossi, JC
Citation
T. Durand et al., Total synthesis of 4(RS)-F-4t-isoprostane methyl ester, TETRAHEDR L, 41(20), 2000, pp. 3859-3862
Citations number
40
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3859 - 3862
Database
ISI
SICI code
0040-4039(20000521)41:20<3859:TSO4ME>2.0.ZU;2-Y
Abstract
The first total synthesis of 4(RS)-F-4t-isoprostane methyl ester I is descr ibed using diacetone-D-glucose as starting material. This new isoprostane ( neuroprostane) would be very useful in neurological studies as a potent lip id peroxidation index to obtain an integrated assessment of oxidative stres s in the human brain. (C) 2000 Elsevier Science Ltd. All rights reserved.