Dioxygenase-catalysed formation of dihydrodiol metabolites of N-methyl-2-pyridone

Authors
Modyanova, L Azerad, R
Citation
L. Modyanova et R. Azerad, Dioxygenase-catalysed formation of dihydrodiol metabolites of N-methyl-2-pyridone, TETRAHEDR L, 41(20), 2000, pp. 3865-3869
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3865 - 3869
Database
ISI
SICI code
0040-4039(20000521)41:20<3865:DFODMO>2.0.ZU;2-X
Abstract
IPTG-induced cells of a recombinant strain of Escherichia coli JM109(DE3)pD TG141 expressing naphthalene dioxygenase from Pseudomonas sp. NCIB 9816-4 o xidized specifically N-methyl-2-pyridone to give the corresponding cis5,6-d ihydro-5,6-dihydroxy derivative as a major product. A small amount of the c is-3,4-dihydro-3,4-dihydroxy isomer was simultaneously formed. (C) 2000 Els evier Science Ltd. All rights reserved.