A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivativesby indium-mediated reduction of 3-iodomethylcephems in aqueous media

Authors
Chae, H Cho, S Keum, G Kang, SB Pae, AN Kim, Y
Citation
H. Chae et al., A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivativesby indium-mediated reduction of 3-iodomethylcephems in aqueous media, TETRAHEDR L, 41(20), 2000, pp. 3899-3901
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3899 - 3901
Database
ISI
SICI code
0040-4039(20000521)41:20<3899:AFSO7A>2.0.ZU;2-6
Abstract
An efficient reductive conversion of 3-iodomethylcephalosporin and 3-acetox ymethylcephalosporin derivatives mediated by indium into the corresponding 3-methylcephems and 3-methylenecephams in moderate to good yields has been developed in an aqueous system. 3-Methylenecephams are converted into the c orresponding 3-methylcephems under previously reported basic conditions qua ntitatively. (C) 2000 Elsevier Science Ltd. All rights reserved.