Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

Authors
Sasaki, M Koike, T Sakai, R Tachibana, K
Citation
M. Sasaki et al., Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid, TETRAHEDR L, 41(20), 2000, pp. 3923-3926
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3923 - 3926
Database
ISI
SICI code
0040-4039(20000521)41:20<3923:TSO(AN>2.0.ZU;2-B
Abstract
A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolat ed from the Micronesian marine sponge Dysidea herbacea, starting from a car bohydrate precursor, is described. The present synthesis features a palladi um(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd. All rights reserved.