Solid phase synthesis of azapeptides utilising reversible amide bond protection to prevent hydantoin formation

Authors
Liley, M Johnson, T
Citation
M. Liley et T. Johnson, Solid phase synthesis of azapeptides utilising reversible amide bond protection to prevent hydantoin formation, TETRAHEDR L, 41(20), 2000, pp. 3983-3985
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
20
Year of publication
2000
Pages
3983 - 3985
Database
ISI
SICI code
0040-4039(20000521)41:20<3983:SPSOAU>2.0.ZU;2-E
Abstract
An efficient method for the solid phase assembly of 'aza-peptides' is descr ibed using Fmoc/tert-butyl chemistry. Elimination of unwanted hydantoin sid e product is achieved with the use of Hmb reversible amide bond protection. (C) 2000 Elsevier Science Ltd. All rights reserved.