Resolution of omeprazole by inclusion complexation with a chiral host BINOL

Authors
Deng, JG Chi, YX Fu, FM Cui, X Yu, KB Zhu, J Jiang, YZ
Citation
Jg. Deng et al., Resolution of omeprazole by inclusion complexation with a chiral host BINOL, TETRAHEDR-A, 11(8), 2000, pp. 1729-1732
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
8
Year of publication
2000
Pages
1729 - 1732
Database
ISI
SICI code
0957-4166(20000505)11:8<1729:ROOBIC>2.0.ZU;2-I
Abstract
Both (S)-(-)- and (R)-(+)-enantiomers of omeprazole were directly resolved by inclusion complexation with a chiral host compound (S)-(-)- or (R)-(+)-2 ,2'-dihydroxy-1,1'-binaphthyl in high enantiomeric excess (> 99% e.e.). (C) 2000 Elsevier Science Ltd. All rights reserved.