A facile method for the synthesis of enantiopure alpha-unsubstituted beta-hydroxy esters

Authors
Wang, YC Hwang, JY Chen, YC Chuang, SC Yan, TH
Citation
Yc. Wang et al., A facile method for the synthesis of enantiopure alpha-unsubstituted beta-hydroxy esters, TETRAHEDR-A, 11(8), 2000, pp. 1797-1800
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
8
Year of publication
2000
Pages
1797 - 1800
Database
ISI
SICI code
0957-4166(20000505)11:8<1797:AFMFTS>2.0.ZU;2-B
Abstract
One-pot deacylation-debromination reactions involving the transesterificati on of the initial chiral beta-bromo-beta-hydroxy thioimide aldol adducts an d subsequent Al-Hg mediated reductive cleavage of the C-Br bond allow for a facile synthesis of enantiopure beta-hydroxy esters. (C) 2000 Published by Elsevier Science Ltd.