HLA-A*6817, identified in the Kolla Amerindians of North-West Argentina possesses a novel nucleotide substitution

Analysis of HLA polymorphism of the indigenous populations of Central and S outh America has identified many alleles not seen previously in other popul ations. We have described a novel allele, B*5113, previously in a Kolla Ame rindian individual from North-West Argentina. Here we present a second nove l allele from this population: A*6817, which differs from its closest neigh bour A*68012 by a single substitution at nucleotide 419. This substitution of adenosine 419 A*68012 for thymidine in A*6817 results in a novel amino a cid change (aspartate to valine) at residue 116.