Congestive heart failure and toxic digoxin levels: Role of cholestyramine

Authors
Roberge, RJ Sorensen, T
Citation
Rj. Roberge et T. Sorensen, Congestive heart failure and toxic digoxin levels: Role of cholestyramine, VET HUM TOX, 42(3), 2000, pp. 172-173
Citations number
24
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY AND HUMAN TOXICOLOGY
ISSN journal
01456296 → ACNP
Volume
42
Issue
3
Year of publication
2000
Pages
172 - 173
Database
ISI
SICI code
0145-6296(200006)42:3<172:CHFATD>2.0.ZU;2-C
Abstract
We report 2 patients with congestive heart failure and concomitant toxic se rum digoxin levels in whom cholestyramine administration increased clearanc e of digoxin and decreased serum digoxin elimination half-lives. Cholestyra mine's gastrointestinal binding of enterohepatically-recycled and enterally -secreted digoxin enhanced elimination, allowing a more rapid return to the rapeutic drug levels.