Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case

Citation
T. Koide et al., Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case, ACT NEUROP, 99(6), 2000, pp. 680-684
Citations number
32
Categorie Soggetti
Neurosciences & Behavoir
Journal title
ACTA NEUROPATHOLOGICA
ISSN journal
00016322 → ACNP
Volume
99
Issue
6
Year of publication
2000
Pages
680 - 684
Database
ISI
SICI code
0001-6322(200006)99:6<680:CAFCNS>2.0.ZU;2-0
Abstract
We report here the case of a 32-year-old woman who suffered from a unique a ngiopathy in the central nervous system (CNS). She died of multiple infarct s in the brain stem and cerebellum during treatment with cyclosporine A aft er bone marrow transplantation for refractory anemia with excess of blasts. The autopsy findings showed segmental narrowing of the basilar artery, in which circumferential dissection of the internal elastic lamina had occurre d. The distal portion of the basilar artery was obstructed by upward disloc ation of the dissected intima. Similar angiopathy was also observed at mult iple sites along the basilar artery branches. These findings suggest endoth elial damage, including vasoconstriction and dissection of the CNS arteries .