Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature

Authors
Herrlinger, U Klingel, K Meyermann, R Kandolf, R Kaiserling, E Kortmann, RD Melms, A Skalej, M Dichgans, J Weller, M
Citation
U. Herrlinger et al., Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature, ACT NEUROP, 99(6), 2000, pp. 709-714
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
ACTA NEUROPATHOLOGICA
ISSN journal
00016322 → ACNP
Volume
99
Issue
6
Year of publication
2000
Pages
709 - 714
Database
ISI
SICI code
0001-6322(200006)99:6<709:CNSHLW>2.0.ZU;2-B
Abstract
A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal mass. Histology revealed primary Hodgkin's lymphoma of the central nervous system with CD30, Epstei n-Barr virus (EBV) latent membrane protein and CD20-positive, CD45 (LCA)-ne gative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded RN A-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected.