5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait

The purpose of this study was to investigate the relationship between bipol ar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (c hromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bip olar patients and 89 normal subjects completed the TPQ questionnaire and we re genotyped for 5-HT2a. Bipolar patients scored higher than normal subject s on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite th e limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor e ffect. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:360-364, 2000. (C) 20 00 Wiley-Liss, Inc.