Is placebo response the same as drug response in panic disorder?

Objective: The authors used seven definitions of response in panic disorder to compare patient-rated improvements in quality of life between patients with panic disorder who responded to sertraline and those who responded to placebo. Method: They combined and examined data from two multicenter, randomized, d ouble-blind, parallel-group, flexible dose studies of panic disorder (N=302 ). Results: Significant differences in quality of life between patients who re sponded to sertraline and those who responded to placebo were apparent acro ss all the definitions of clinical response. Conclusions: Patients who respond to placebo in panic disorder treatment st udies may show symptom relief but may not experience improvement in quality of life. Determinations of quality of life should be included as component s of both standard clinical assessment and clinical treatment studies of pa tients with panic disorder.