Mechanisms of neurodegenerative disorders part 1: Protein aggregates

Despite a vast array of causes of neurodegenerative diseases, research has identified common pathways through which the neurodegeneration proceeds. Pa rt I of this neurological review article will address a confluence of resea rch suggesting that neurodegeneration is often linked with the accumulation of insoluble pro rein aggregates; part 2, the mechanisms through which neu rodegeneration occurs-apoptosis, necrosis, and excitotoxicity. Along with t he common mechanisms for inducing neurodegeneration, we will also review co mmon defense mechanisms that protect against toxic insults. Each of these p athways offers potential targets for pharmaceutical intervention.