LRDD, a novel leucine rich repeat and death domain containing protein

Citation
Jb. Telliez et al., LRDD, a novel leucine rich repeat and death domain containing protein, BBA-PROT ST, 1478(2), 2000, pp. 280-288
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
ISSN journal
01674838 → ACNP
Volume
1478
Issue
2
Year of publication
2000
Pages
280 - 288
Database
ISI
SICI code
0167-4838(20000523)1478:2<280:LANLRR>2.0.ZU;2-V
Abstract
Death domains (DD) and leucine rich repeats (LRR) are two different types o f protein interaction motifs. Death domains are found predominantly in prot eins involved in signaling and are involved in homo- and heteromultimerizat ion. Leucine rich repeats are found in proteins with diverse cellular funct ions, like cell adhesion and cellular signaling, and mediate reversible pro tein-protein interactions. In this paper we report the cloning of a new hum an gene called LRDD (leucine repeat death domain containing protein). LRDD encodes a protein of 83 kDa with six LRRs at the N-terminus and a DD at the C-terminus. LRDD appears to be processed into two fragments of about 33 an d 55 kDa, containing LRRs and DD respectively. Interestingly, LRDD is shown to interact with two other death domain containing proteins, FADD and MADD , presumably through death domain interactions. LRDD may represent a new ty pe of adapter protein that could be involved in signaling or other cellular functions. (C) 2000 Elsevier Science B.V. All rights reserved.