A randomised study of allogeneic transplantation with stem cells from blood or bone marrow

Citation
D. Heldal et al., A randomised study of allogeneic transplantation with stem cells from blood or bone marrow, BONE MAR TR, 25(11), 2000, pp. 1129-1136
Citations number
42
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
02683369 → ACNP
Volume
25
Issue
11
Year of publication
2000
Pages
1129 - 1136
Database
ISI
SICI code
0268-3369(200006)25:11<1129:ARSOAT>2.0.ZU;2-G
Abstract
Sixty-one consecutive adult patients with leukaemia, primary myelofibrosis or myelodysplastic syndrome with an HLA-identical or one antigen mismatched family donor were randomised to allogeneic transplantation with PBPC or BM . Progenitor cells were mobilised into the blood by giving the donors 10 mu g/kg/day G-CSF subcutaneously for 5-7 days. G-CSF was not given to patient s after transplantation. The time to neutrophil counts >0.5 x 10(9)/l was 1 7 days (95% CI 15.2-18.8 days) in the PBPC group compared to 23 (95 % CI 20 .3-25.7 days) in the BM group (P = 0.0005). The time to platelet counts >20 x 10(9)/l was 13 days (95% CI 11.7-14.3 days) in the PBPC group and 21 day s (95% CI 18.7-23.3 days) in the BM group (P = 0.0005), Acute GVHD of grade s II-IV developed in six patients transplanted with PBPC and three patients transplanted. with BM. The numbers of patients with chronic GVHD were 15 a nd 8, respectively. Transplant-related mortality and leukaemia-free surviva l showed no significant differences. Transplantation with PBPC appears pref erable for the recipient due to faster neutrophil and platelet recovery. Ho wever, the final conclusion can not be drawn before long-term results on ch ronic GVHD and relapse incidence in longer randomised trials are available.