A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase

We report here a case of donor cell leukemia in a female Ph-positive CML pa tient who received an allogeneic BRIT from her HLA-identical brother in the chronic phase and subsequently developed a donor cell Ph-positive ALL. The number of cases of donor cell leukemia after BRIT so far reported is less than 20 and in this case, as in the first cases reported by Marmont Et al a nd McCane et al. the original leukemia and donor cell leukemia share the pr esence of a Ph chromosome. Furthermore, we analyzed the patient during diff erent stages of her disease by RT-PCR and determined the type of bcr-abl ju nctions (M bcr-abl junction; b3a2 transcript, p210) in both the recipient a nd donor cell leukemia.