Trichosporon beigelii infection: experience in a regional burn center

Trichosporon beigelii is a fungus once thought to cause only superficial in fections, but recently has been increasingly identified as an opportunistic systemic pathogen in immunocompromised patients. There have been very limi ted reports of this organism in the burn patient population. We describe th e first report of pharmacological management of invasive T. beigelii with a combination of amphotericin B and high dose fluconazole in a burn patient. Antifungal susceptibility testing of T. beigelii determined a change in mi nimum inhibitory concentrations (MICs) of amphotericin B and a consistent r esistance pattern with the use of flucytosine. This paper will review our e xperience with T. beigelii fungus in a regional burn treatment center and r eview the literature on other experiences in the burn population. (C) 2000 Published by Elsevier Science Ltd and ISBI. All rights reserved.