Interaction between Sp1 and cell cycle regulatory proteins is important intransactivation of a differentiation-related gene

Citation
Og. Opitz et Ak. Rustgi, Interaction between Sp1 and cell cycle regulatory proteins is important intransactivation of a differentiation-related gene, CANCER RES, 60(11), 2000, pp. 2825-2830
Citations number
20
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
00085472 → ACNP
Volume
60
Issue
11
Year of publication
2000
Pages
2825 - 2830
Database
ISI
SICI code
0008-5472(20000601)60:11<2825:IBSACC>2.0.ZU;2-T
Abstract
The stratified squamous epithelium is a model system in which to define mol ecular mechanisms underlying the switch from proliferation to differentiati on. This can be achieved through the functional dissection of keratin gene promoters, Having previously established the importance of keratin 4 in mai ntaining the differentiated phenotype in corneal epithelial cells, we inves tigated the role of Sp1-mediated transactivation of the keratin 4 promoter given the role of Sp1 in differentiation and fell cycle progression. Sp1 tr ansactivation of the keratin 4 promoter was diminished in cyclin D1-overexp ressing cells, which may be mediated through a newly described direct inter action between Sp1 and cyclin D1 and opposed by a complex between Sp1 and p RB.