H. Iyori et al., THROMBOCYTOPENIA IN NEONATES BORN TO WOMEN WITH AUTOIMMUNE THROMBOCYTOPENIC PURPURA, Pediatric hematology and oncology, 14(4), 1997, pp. 367-373
We conducted a survey by questionnaire to clarify the actual condition
s of neonates born to mothers with autoimmune thrombocytopenic purpura
(ATP) in Japan. We investigated 93 pregnancies (1 resulting in twins)
in 31 hospitals between 1985 and 1994. Forty-nine of the neonates (52
%) had thrombocytopenia (below 150 x 10(9)/L). Nineteen neonates (20%)
showed a bleeding tendency, but this was generally mild. In only one
neonate (1%) (a case of asymptomatic intracranial hemorrhage, ICH), de
ep bleeding occurred due to thrombocytopenia. The lowest platelet coun
t of neonates after birth occurred on day 4, not on day 0. There was n
o correlation between maternal and neonatal platelet counts. However,
there was an apparent correlation between rite neonatal platelet count
on day 0 and the lowest platelet count after birth. Treatment of the
mothers with intravenous high-dose gamma-globulin and prednisolone did
not prevent risk of neonatal thrombocytopenia significantly.