Inverse relation between plasma C-CSF levels and neutrophil counts in a patient with autoimmune neutropenia treated with G-CSF

Authors
Vlasveld, LTH Ermens, AAM
Citation
Lth. Vlasveld et Aam. Ermens, Inverse relation between plasma C-CSF levels and neutrophil counts in a patient with autoimmune neutropenia treated with G-CSF, CLIN LAB H, 22(2), 2000, pp. 119-120
Citations number
7
Categorie Soggetti
Hematology
Journal title
CLINICAL AND LABORATORY HAEMATOLOGY
ISSN journal
01419854 → ACNP
Volume
22
Issue
2
Year of publication
2000
Pages
119 - 120
Database
ISI
SICI code
0141-9854(200004)22:2<119:IRBPCL>2.0.ZU;2-0
Abstract
The pharmacokinetic characteristics of granulocyte colony-stimulating facto r (G-CSF) appears to be related to the neutrophil count, We report the case of an 81-year-old male with acquired antibody induced neutropenia treated with G-CSF. This produced a rapid increase in the neutrophil count which ap peared to be associated with diminished trough plasma G-CSF levels. Our dat a appears to indicate that mature neutrophils may play a part in the cleara nce of G-CSF from plasma.