Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+) cells

Authors
Thulesen, S Nielsen, M Petersen, TR Nissen, MH Odum, N Ropke, C
Citation
S. Thulesen et al., Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+) cells, CYTOKINE, 12(6), 2000, pp. 751-755
Citations number
15
Categorie Soggetti
Cell & Developmental Biology
Journal title
CYTOKINE
ISSN journal
10434666 → ACNP
Volume
12
Issue
6
Year of publication
2000
Pages
751 - 755
Database
ISI
SICI code
1043-4666(200006)12:6<751:I1IAGF>2.0.ZU;2-A
Abstract
The effects of IL-15, as compared to IL-2, on growth of human thymocytes ha s been evaluated. Expression of comparable amounts of receptor chains was f ound on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+) thymocy te growth, whereas CD4(+) cells proliferated to a higher extent in IL-2 cul tures, CD4(+) 8(+) and CD4(-) 8(-) thymocytes expanded equally well in both culture types. (C) 2000 Academic Press.