MULTIFOCAL OSTEOSARCOMA IN A PATIENT WITH FANCONI-ANEMIA

Purpose: The purpose of this report is to present a case of multifocal osteosarcoma in a patient with Fanconi anemia. Patients and Methods: A nine year old girl with known Fanconi anemia presented with a pathol ogic femur fracture. Imaging studies confirmed soft tissue and bony in volvement in the femur, ipsilateral tibia, and possibly contralateral femur. Results: Biopsy and subsequent amputation confirmed the presenc e of classic osteosarcoma in the involved femur and ipsilateral tibia. The patient died seven months later of pulmonary failure secondary to metastases. Conclusion: Fanconi anemia is known to be associated with malignancies such as leukemias. We report a new association of Fancon i anemia with osteosarcoma.